MatchFund

Pre-seed Deeptech Investors in the US

We've mapped 15 of the most active pre-seed Deeptech investors funding founders in the US, with cheques $25K–$100M.

Stages they backof 15 firms
  • Pre-seed15
  • Seed15
  • Series A12
  • Series B10
  • Series C+10
A firm counts at every stage it invests in.

We've mapped 15 of the most active pre-seed Deeptech investors funding founders in the US — 15 VCs. Cheque sizes across this segment run $25K–$100M.

When raising pre-seed for a Deeptech company in the US, founders should lead with the investors whose stage and cheque size actually match the round — not just the best-known names. 15 of these profiles have been verified in the last review pass. Sign in to see each investor's full thesis, cheque range, and how closely they fit your specific company.

VC
Verified May 2026
Applied Ventures logo

Applied Ventures

Pre-seed to Series C+
🇺🇸US
AI/MLClimateDeeptech+5 more

Applied Ventures is the corporate venture capital arm of Applied Materials (NASDAQ: AMAT), founded 2006 and based in Santa Clara, CA. Sign in to see full profile →

VC
Verified Nov 2026
Khosla Ventures logo

Khosla Ventures

Pre-seed to Series C+
🇺🇸US
AI/MLBiotechClimate+9 moreGeneralist

Khosla Ventures is a Menlo Park, California venture capital firm founded in 2004 by Vinod Khosla. Sign in to see full profile →

VC
Verified Nov 2026
First Round Capital logo

First Round Capital

Pre-seed to Series A
🇺🇸US
AI/MLClimateConsumer+7 moreGeneralist

First Round Capital is a US seed-stage venture firm founded in 2004 by Josh Kopelman and Howard Morgan, with offices in San Francisco (HQ), New York and Phil… Sign in to see full profile →

VC
Verified Nov 2026
Eclipse logo

Eclipse

Pre-seed to Series C+
🇺🇸US
HealthtechMobilityRobotics+5 more

Palo Alto VC with $2B+ AUM investing in physical-economy startups: manufacturing, logistics, supply chain, energy, defense, robotics. Sign in to see full profile →

VC
Verified Nov 2026
8VC logo

8VC

Pre-seed to Series C+
🇺🇸US
AI/MLBiotechClimate+7 more

8VC is an Austin, Texas technology investment firm founded in 2015 by Joe Lonsdale after the wind-down of Formation 8. Sign in to see full profile →

VC
Verified Nov 2026
Lux Capital logo

Lux Capital

Pre-seed to Series C+
🇺🇸US
AI/MLBiotechClimate+7 more

Lux Capital is a New York-based science and tech VC (founded 2000 by Peter Hebert, Robert Paull, and Josh Wolfe) with $7B+ AUM. Sign in to see full profile →

VC
Verified Nov 2026
Spark Capital logo

Spark Capital

Pre-seed to Series C+
🇺🇸US
AI/MLClimateConsumer+7 more

Invests in: Europe, Israel, USA, Canada, Asia, Worldwide VC firm investing and partnering with world-changing in companies. Sign in to see full profile →

VC
Verified Nov 2026
Greylock logo

Greylock

Pre-seed to Series C+
🇺🇸US
HealthtechSaaSAI/ML+8 more

Greylock is a venture capital firm founded in 1965 and headquartered in Menlo Park, California, that focuses on early-stage companies; most of its investment… Sign in to see full profile →

VC
Verified Nov 2026
DCVC logo

DCVC

Pre-seed to Series C+
🇺🇸US
CyberSaaSFood & Ag+8 more

DCVC (Data Collective) is a deep-tech venture capital firm founded in 2010 by Matt Ocko and Zachary Bogue, with offices in Palo Alto and San Francisco. Sign in to see full profile →

VC
Verified Nov 2026
Gaingels logo

Gaingels

Pre-seed to Series C+
🇺🇸US
AI/MLHealthtechFintech+4 more

Investor community of LGBTQ+ people and allies that co-invests with select venture capital leads in companies building diverse and inclusive teams, from seed… Sign in to see full profile →

VC
Verified Nov 2026
South Park Commons logo

South Park Commons

Pre-seed to Seed
🇺🇸US
SaaSIndustrialAI/ML+5 moreGeneralist

San Francisco-based community for founders and technologists exploring what to build, with spaces in San Francisco, New York and Bengaluru. Sign in to see full profile →

VC
Verified Nov 2026
AlleyCorp logo

AlleyCorp

Pre-seed to Seed
🇺🇸US
ConsumerEdTechHealthtech+1 moreGeneralist

Looking at companies from the idea stage to 50K+ in MRR We are tech pioneers, investors, and entrepreneurs. We build and invest in transformative companies Sign in to see full profile →

VC
Verified Nov 2026
Madrona Venture Group logo

Madrona Venture Group

Pre-seed to Series C+
🇺🇸US
AI/MLSaaSCyber+4 more

Seattle-based VC backing founding teams at seed, early and acceleration stages in Seattle, the Bay Area and beyond, across AI and intelligent apps, enterpris… Sign in to see full profile →

VC
Verified Nov 2026
Pear VC logo

Pear VC

Pre-seed to Seed
🇺🇸US
AI/MLBiotechHealthtech+3 moreGeneralist

Pre-seed and seed VC in Palo Alto backing founders from idea to early traction across consumer, SaaS, enterprise, healthcare, fintech, AI and deep tech. Sign in to see full profile →

VC
Verified Nov 2026
Initialized Capital logo

Initialized Capital

Pre-seed to Series A
🇺🇸US
AI/MLClimateWeb3+7 more

Seed-stage VC with offices in San Francisco and New York, backing founders across enterprise SaaS, sustainability, health, hard tech, AI, infrastructure, con… Sign in to see full profile →

Directory last updated: November 2026.

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