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Seed Deeptech Investors in the US

We've mapped 20 of the most active seed Deeptech investors funding founders in the US, with cheques $100Kโ€“$500M.

Stages they backof 20 firms
  • Pre-seed8
  • Seed20
  • Series A19
  • Series B17
  • Series C+15
A firm counts at every stage it invests in.

We've mapped 20 of the most active seed Deeptech investors funding founders in the US โ€” 20 VCs. Cheque sizes across this segment run $100Kโ€“$500M.

When raising seed for a Deeptech company in the US, founders should lead with the investors whose stage and cheque size actually match the round โ€” not just the best-known names. 20 of these profiles have been verified in the last review pass. Sign in to see each investor's full thesis, cheque range, and how closely they fit your specific company.

VC
Verified Nov 2026
M12 logo

M12

Seed to Series B
๐Ÿ‡บ๐Ÿ‡ธUS
AI/MLRoboticsSaaS+3 more

Microsoft's venture capital fund, investing in seed through Series B companies in AI apps, security for AI, AI cloud infrastructure, AI data ops and models, โ€ฆ Sign in to see full profile โ†’

VC
Verified Nov 2026
IBM Ventures logo

IBM Ventures

Seed to Series C+
๐Ÿ‡บ๐Ÿ‡ธUS
AI/MLClimateCyber+2 more

IBM's $500M+ corporate venture arm backing early-stage AI, quantum, security, data, sustainability startups. Sign in to see full profile โ†’

VC
Verified Nov 2026
Foothill Ventures logo

Foothill Ventures

Seed
๐Ÿ‡บ๐Ÿ‡ธUS
AI/MLBiotechCyber+5 more

Silicon Valley seed-stage deep-tech VC (rebranded from Tsingyuan Ventures to Foothill Ventures in 2021); invests in software, life science and frontier hard โ€ฆ Sign in to see full profile โ†’

VC
Verified May 2026
Applied Ventures logo

Applied Ventures

Pre-seed to Series C+
๐Ÿ‡บ๐Ÿ‡ธUS
AI/MLClimateDeeptech+5 more

Applied Ventures is the corporate venture capital arm of Applied Materials (NASDAQ: AMAT), founded 2006 and based in Santa Clara, CA. Sign in to see full profile โ†’

VC
Verified May 2026
11.2 Capital logo

11.2 Capital

Seed to Series A
๐Ÿ‡บ๐Ÿ‡ธUS
AI/MLBiotechCyber+5 more

Early-stage VC investing in breakthrough deep tech: AI, cybersecurity, quantum, robotics, new space, bioengineering, climate. Sign in to see full profile โ†’

VC
Verified Nov 2026
Andreessen Horowitz logo

Andreessen Horowitz

Seed to Series C+
๐Ÿ‡บ๐Ÿ‡ธUS
AI/MLBiotechWeb3+2 moreGeneralist

Venture capital firm founded in 2009 by Marc Andreessen and Ben Horowitz, with over $100B under management. Sign in to see full profile โ†’

VC
Verified Nov 2026
Accel logo

Accel

Seed to Series C+
๐Ÿ‡บ๐Ÿ‡ธUS
MobilityRoboticsAI/ML+7 moreGeneralist

Accel is a venture capital firm founded in 1983 and based in Palo Alto, with offices in San Francisco, London and India. Sign in to see full profile โ†’

VC
Verified Nov 2026
Lightspeed Venture Partners logo

Lightspeed Venture Partners

Seed to Series C+
๐Ÿ‡บ๐Ÿ‡ธUS
AI/MLConsumerCyber+5 more

Lightspeed Venture Partners is a global, multi-stage venture capital firm headquartered in Menlo Park, California, investing from seed through growth and latโ€ฆ Sign in to see full profile โ†’

VC
Verified Nov 2026
Sequoia Capital logo

Sequoia Capital

Seed to Series C+
๐Ÿ‡บ๐Ÿ‡ธUS
AI/MLClimateHealthtech+5 more

VC firm that partners with founders early, sometimes when a company is no more than an idea, and helps them build companies from idea to IPO and beyond. Sign in to see full profile โ†’

VC
Verified Nov 2026
General Catalyst logo

General Catalyst

Seed to Series C+
๐Ÿ‡บ๐Ÿ‡ธUS
MarketplacesAI/MLBiotech+10 more

Venture firm that creates new companies from scratch, partners with founders at seed and supports companies on a more enduring growth path, alongside a Custoโ€ฆ Sign in to see full profile โ†’

VC
Verified Nov 2026
Khosla Ventures logo

Khosla Ventures

Pre-seed to Series C+
๐Ÿ‡บ๐Ÿ‡ธUS
AI/MLBiotechClimate+9 moreGeneralist

Khosla Ventures is a Menlo Park, California venture capital firm founded in 2004 by Vinod Khosla. Sign in to see full profile โ†’

VC
Verified Nov 2026
First Round Capital logo

First Round Capital

Pre-seed to Series A
๐Ÿ‡บ๐Ÿ‡ธUS
AI/MLClimateConsumer+7 moreGeneralist

First Round Capital is a US seed-stage venture firm founded in 2004 by Josh Kopelman and Howard Morgan, with offices in San Francisco (HQ), New York and Philโ€ฆ Sign in to see full profile โ†’

VC
Verified Nov 2026
Eclipse logo

Eclipse

Pre-seed to Series C+
๐Ÿ‡บ๐Ÿ‡ธUS
HealthtechMobilityRobotics+5 more

Palo Alto VC with $2B+ AUM investing in physical-economy startups: manufacturing, logistics, supply chain, energy, defense, robotics. Sign in to see full profile โ†’

VC
Verified Nov 2026
Bessemer Venture Partners logo

Bessemer Venture Partners

Seed to Series C+
๐Ÿ‡บ๐Ÿ‡ธUS
AI/MLBiotechConsumer+7 more

Bessemer Venture Partners is a US-headquartered multi-stage venture capital firm investing globally from seed through growth across cloud/SaaS, AI & ML, cybeโ€ฆ Sign in to see full profile โ†’

VC
Verified Nov 2026
8VC logo

8VC

Pre-seed to Series C+
๐Ÿ‡บ๐Ÿ‡ธUS
AI/MLBiotechClimate+7 more

8VC is an Austin, Texas technology investment firm founded in 2015 by Joe Lonsdale after the wind-down of Formation 8. Sign in to see full profile โ†’

VC
Verified Nov 2026
GV logo

GV

Seed to Series C+
๐Ÿ‡บ๐Ÿ‡ธUS
AI/MLBiotechClimate+10 more

GV (formerly Google Ventures) is the venture capital arm of Alphabet, founded in 2009 and headquartered in Mountain View with offices in San Francisco, Cambrโ€ฆ Sign in to see full profile โ†’

VC
Verified Nov 2026
Lux Capital logo

Lux Capital

Pre-seed to Series C+
๐Ÿ‡บ๐Ÿ‡ธUS
AI/MLBiotechClimate+7 more

Lux Capital is a New York-based science and tech VC (founded 2000 by Peter Hebert, Robert Paull, and Josh Wolfe) with $7B+ AUM. Sign in to see full profile โ†’

VC
Verified Nov 2026
Spark Capital logo

Spark Capital

Pre-seed to Series C+
๐Ÿ‡บ๐Ÿ‡ธUS
AI/MLClimateConsumer+7 more

Invests in: Europe, Israel, USA, Canada, Asia, Worldwide VC firm investing and partnering with world-changing in companies. Sign in to see full profile โ†’

VC
Verified Nov 2026
Felicis Ventures logo

Felicis Ventures

Seed to Series B
๐Ÿ‡บ๐Ÿ‡ธUS
AI/MLBiotechClimate+9 more

Felicis is a US multi-stage venture capital firm founded in 2006 by Aydin Senkut (Google's first product manager) and headquartered at 2460 Sand Hill Road, Mโ€ฆ Sign in to see full profile โ†’

VC
Verified Nov 2026
Greylock logo

Greylock

Pre-seed to Series C+
๐Ÿ‡บ๐Ÿ‡ธUS
HealthtechSaaSAI/ML+8 more

Greylock is a venture capital firm founded in 1965 and headquartered in Menlo Park, California, that focuses on early-stage companies; most of its investmentโ€ฆ Sign in to see full profile โ†’

Directory last updated: November 2026.

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